Morecambe look set to be without striker Paul Mullin, who is rated as a major doubt as he struggles to overcome a hamstring injury.
Manager Sammy McIlroy will be looking for his side to build on their 1-0 win over high-flying Port Vale last week.
Northampton Town manager Ian Sampson told BBC Look East: "Ryan Gilligan is only 23 years old and he's well worth his 200 games.
Sampson will not underestimate Morecambe
"At home, we've been quite successful. We're looking to take three points but Morecambe had a great result against Port Vale, who were top of the league.
"It shows they've got something in their squad. It's that type of division. If you perform well, you can beat anyone. We'll go into it full of confidence."
Source: BBC Sport
Source: BBC Sport