Oxford could hand a debut to striker Tom Craddock, who joined from non-league Luton earlier this week.Fellow deadline day signing Josh Payne could keep his place in midfield after making his debut during the Johnstone's Paint Trophy defeat by Aldershot.
Morecambe goalkeeper Barry Roche is expected to shake off a persistent ligament problem in time for the game.
Boss Sammy McIlroy will check on the fitness of defender Paul Scott, who has been suffering from illness.
Source: BBC Sport
Source: BBC Sport